gotta love a good prank. I do alot of office ones around here, when i'm bored.. which is most of the time. these are my fav's for those that work in an office.
1) if you sit near someones computer, plug in an extra usb keyboard to their computer and have it hidden on your side. I have a "battleship partner" so our desks are facing eachother and our screens are back to back, giving me perfect access to the back of his pc

then randomly while they're working away use the keyboard to type extra things on their screen, or rotate their documents (ctrl+shift+plus i think) their faces are priceless. Or you can lock them out of things while they're working. Lenny was on the phone with IT trying to figure out why his computer was freaking out on him
2) if you have a copy center like a central area with common printer/copier that everyone uses, hide the staplers and put a box of paperclips there so everyone will try and use them. But before you leave the paperclip box, clip every one of them together. (this is time consuming but oh so worth it) so they'll go to grap a paperclip... and pull out a string of them... and the string keeps going.... then they throw it back in and try and grab from a different part of the box... but it's still connected
3) very easy one. take a post it and trim it small enough to just cover the bottom of someones mouse, they'll be very confused why their mouse doesn't work. Or if they leave the computer unlocked, change their mouse settings to left handed. so a right click=left click and vise versa, that's a tough one to figure out haha
4)and lastly, i learned this one from the TV show the office, if someone sits near a corner or something. Every time they leave, push their desk 1 inch closer to the corner. Eventually they'll be climbing over stuff to get into their desk or in a very cramped small area and not know why but it's hilarious the moment they realize it
oh ya and my ABSOLUTE FAVORITE:
while someone is away from their desk, take a print screen of their desktop. make sure the mouse is off in the corner so it's not in the middle of the picture. hit ctrl+prnt scrn and paste it into ms paint or something and save it as a picture. Next make a new folder on the desktop (they wont notice one extra) and drop ALL of the desktop icons in the folder so the desktop is totally clear. Now, take the picture you saved of their desktop and make it the background. The end result is that at a glance, it looks like the exact same desktop, except now all the icons are pictures.... so when they go to click something and open it, nothing happens because it's not really an icon it's just a picture of said icon.

(but of course all their stuff is saved conveniently in the extra folder you made so nothing has been deleted, cuz that's just a dick move haha)