My favorite is Route 20 in Washington state. It was rated many years ago by Car & Driver as one of the top 10 roads in America. It's still an awesome drive, with a fairly big river running longside as you go up over the pass. It's closed during the winter.
Here's some video of various sections of the highway.
The video here is just after I got my GoPro, and took it for a test run on my favorite road. Pardon the rattling...I hadn't shimmed the camera mount yet.
Basically, I've been doing a cruise over this pass to Winthrop each Spring in May. We'll be doing it for the 3rd time this year on May 5th (Check out the Pacific Northwest Section for more info).