My fiancé bought it for me today and I've put in about 2 hours of gameplay. If you liked the first one you'll like the sequel. You know have a melee weapon as well as a couple of added abilities. I was also able to start the game using my data from Infamous.
The controls and gameplay are identical from what I remember. One exception is that the dead drops aren't found on rooftops via satellite links. They are now carrier pigeons carrying USBs. You must stun them to get them to drop from the sky. The main boss of this game is The Beast and you encounter him briefly in the game's opening sequence. He destroys Empire Island and you make way for New Marais which is supposed to be New Orleans. You now have to fight a militia which is controlling the city since the floods. You'll also encounter some "freaks". Freaks are mutants and not some kinky prostitute.
All in all it's been an enjoyable game thus far and I'm looking forward to putting some more time into it.
Anyone else played it yet?